Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP2 | P42575 | 1/20 | 0.44 |
| ▸ | CASP4 | P49662 | 1/20 | 0.44 |
| ▸ | CASP5 | P51878 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.44 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.44 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964310 | 0.92 | CASP1 (0.45) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL1931615 | 0.88 | ABCB1 (0.46) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL7934107 | 0.84 | CASP1 (0.44) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL4051763 | 0.82 | PREP (0.43) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL8008130 | 0.82 | SYK (0.45) | PREPCTSL | |
| SCHEMBL12553013 | 0.81 | CASP1 (0.40) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL23386199 | 0.77 | CASP1 (0.44) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL12237104 | 0.77 | CTSL (0.47) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL2228500 | 0.76 | ABCB1 (0.43) | CASP1CASP3CASP2CASP4CASP5 | |
| SCHEMBL20484674 | 0.76 | ACE (0.60) | CASP1CASP3CASP2CASP4CASP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2312947-B1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLC (US) | 2014-01-01 | — | — | EP | disclosed |