Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 4/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP5 | P51878 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008130 | 0.90 | SYK (0.45) | PREPCTSL | |
| SCHEMBL14964310 | 0.84 | CASP1 (0.45) | PREPCAPN1CASP1CASP3CASP2 | |
| SCHEMBL16474261 | 0.82 | CASP1 (0.44) | PREPCAPN1CASP1CASP3CASP2 | |
| SCHEMBL1931615 | 0.81 | ABCB1 (0.46) | PREPCAPN1CASP1CASP3CASP2 | |
| SCHEMBL4065908 | 0.78 | PREP (0.56) | PREPCTSKCTSLCTSSCYP3A4 | |
| SCHEMBL5905807 | 0.78 | PREP (0.50) | PREP | |
| SCHEMBL7934107 | 0.77 | CASP1 (0.44) | PREPCAPN1CASP1CASP3CASP2 | |
| SCHEMBL12553013 | 0.75 | CASP1 (0.40) | PREPCAPN1CASP1CASP3CASP2 | |
| SCHEMBL3229214 | 0.73 | HRH4 (0.42) | — | |
| SCHEMBL8007264 | 0.71 | PREP (0.53) | PREPCTSKCTSLCTSSCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |