SCHEMBL1647438

SCHEMBL1647438

COC(=O)c1cc(C(=O)O)ccc1O

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 6/20 0.65
CA1 P00915 6/20 0.65
CA2 P00918 6/20 0.65
CA7 P43166 6/20 0.65
CA9 Q16790 6/20 0.65
CA14 Q9ULX7 6/20 0.65
HTT P42858 2/20 0.58
XDH P47989 1/20 0.56
KDM4E B2RXH2 4/20 0.53
MAPT P10636 3/20 0.53
GAA P10253 3/20 0.53
PTGS2 P35354 2/20 0.53
CA4 P22748 2/20 0.53
CA6 P23280 2/20 0.53
POLB P06746 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
TSHR P16473 2/20 0.53
LMNA P02545 2/20 0.53
HPGD P15428 3/20 0.51
HSD17B10 Q99714 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL403210 0.89 CA12 (0.71) CA12CA1CA2CA7CA9
SCHEMBL1483249 0.85 CA12 (0.65) CA12CA1CA2CA7CA9
SCHEMBL330670 0.85 CA12 (0.65) CA12CA1CA2CA7CA9
SCHEMBL136284 0.85 CA1 (0.67) CA12CA1CA2CA7CA9
SCHEMBL31258831 0.85 CA12 (0.65) CA12CA1CA2CA7CA9
SCHEMBL820141 0.85 KDM4E (0.55) CA12CA1CA2CA7CA9
SCHEMBL29699657 0.85 KDM4E (0.55) CA12CA1CA2CA7CA9
SCHEMBL4424415 0.84 CA1 (0.62) CA12CA1CA2CA7CA9
SCHEMBL293611 0.83 KDM4E (0.55) CA12CA1CA2CA7CA9
SCHEMBL293610 0.83 KDM4E (0.53) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250312504-A1 VOLATILE COMPOSITION DISPENSER FOR COMPOSITIONS COMPRISING A META-(C1-C4 ALKOXY) SALICYLALDEHYDE THE PROCTER & GAMBLE COMPANY 2025-10-09 US disclosed
EP-4573087-A1 USE OF (ISOINDOLIN-2-YL)(4-HYDROXY-3-(ISOINDOLINE-2-CARBONYL)PHENYL)METHANONES IN THE TREATMENT OF TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PROTEIN 1 DYSFUNCTION University of Notre Dame du Lac (US) 2025-06-25 EP disclosed
CN-118255698-A Sulfonamide compound and preparation method and application thereof 海南大学 2024-06-28 CN disclosed
US-20240199997-A1 COMPOSITIONS COMPRISING A META-(C1-C4 ALKOXY) SALICYLALDEHYDE PROCTER & GAMBLE COMPANY, THE 2024-06-20 US disclosed
WO-2024044553-A1 USE OF (ISOINDOLIN-2-YL)(4-HYDROXY-3-(ISOINDOLINE-2-CARBONYL)PHENYL)METHANONES IN THE TREATMENT OF TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PROTEIN 1 DYSFUNCTION UNIVERSITY OF NOTRE DAME DU LAC (US) 2024-02-29 WO disclosed
WO-2024044553-A1 USE OF (ISOINDOLIN-2-YL)(4-HYDROXY-3-(ISOINDOLINE-2-CARBONYL)PHENYL)METHANONES IN THE TREATMENT OF TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PROTEIN 1 DYSFUNCTION UNIVERSITY OF NOTRE DAME DU LAC (US) 2024-02-29 WO disclosed
EP-2483254-B1 NOVEL COMPOUNDS GLAXO GROUP LTD (GB) 2014-08-13 EP disclosed
US-8778939-B2 Compounds GLAXO GROUP LIMITED (GB) 2014-07-15 US disclosed
EP-2483254-A1 NOVEL COMPOUNDS Glaxo Group Limited (GB) 2012-08-08 EP disclosed
US-20120184553-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-07-19 US disclosed
WO-2011038572-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2011-04-07 WO disclosed
US-7358249-B2 Heterocyclic compounds having inhibitory activity against HIV integrase SHIONOGI & CO., LTD. (JP) 2008-04-15 US disclosed
US-5017569-A Cephalosporin derivatives ICI PHARMA (FR) 1991-05-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120184553-A1 NOVEL COMPOUNDS LRRK2, PARK7, PINK1 CA12 4873/4885CA1 4717/4885CA2 4695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.