Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 9/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.58 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.57 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.56 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5699793 | 0.87 | CCR5 (0.58) | CCR5LRRK2PTGER1STAT3 | |
| SCHEMBL1646798 | 0.87 | CCR5 (0.58) | CCR5LRRK2STAT3 | |
| SCHEMBL384896 | 0.86 | FOLH1 (0.68) | LRRK2FOLH1PTGER1 | |
| SCHEMBL5699665 | 0.86 | CCR5 (0.57) | CCR5LRRK2PTGER1STAT3 | |
| SCHEMBL1647819 | 0.85 | LRRK2 (0.60) | CCR5LRRK2FOLH1PTGER1 | |
| SCHEMBL1648397 | 0.85 | LRRK2 (0.67) | CCR5LRRK2MRGPRX4FOLH1PTGER1 | |
| SCHEMBL5699779 | 0.84 | CCR5 (0.58) | CCR5LRRK2MRGPRX4PTGER1STAT3 | |
| SCHEMBL5699892 | 0.83 | CCR5 (0.62) | CCR5LRRK2PTGER1STAT3 | |
| SCHEMBL1647514 | 0.83 | LRRK2 (0.61) | CCR5LRRK2MRGPRX4FOLH1PTGER1 | |
| SCHEMBL1646591 | 0.83 | LRRK2 (0.61) | CCR5LRRK2MRGPRX4FOLH1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-B1 | NOVEL COMPOUNDS | GLAXO GROUP LTD (GB) | 2014-08-13 | — | — | EP | disclosed |
| US-8778939-B2 | Compounds | GLAXO GROUP LIMITED (GB) | 2014-07-15 | — | — | US | disclosed |
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| US-20120184553-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-07-19 | — | — | US | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184553-A1 | NOVEL COMPOUNDS | LRRK2, PARK7, PINK1 | CCR5 4017/4885LRRK2 1/4885MRGPRX4 4115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.