Sugi Predict

Sugi Predict / Compounds / Indole

Indole

Indole

SCHEMBL1647849

c1ccc2[nH]ccc2c1.c1ccc2scnc2c1

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.61
▸ HSD17B10 Q99714 2/20 0.61
▸ TRPA1 O75762 1/20 0.55
▸ CA1 P00915 1/20 0.55
▸ CA2 P00918 1/20 0.55
▸ ITGB2 P05107 1/20 0.55
▸ ICAM1 P05362 1/20 0.55
▸ ITGAL P20701 1/20 0.55
▸ CA4 P22748 1/20 0.55
▸ CA6 P23280 1/20 0.55
▸ AHR P35869 1/20 0.55
▸ ADK P55263 1/20 0.55
▸ GOT1 P17174 1/20 0.37
▸ RIPK1 Q13546 1/20 0.36
▸ NPC1 O15118 4/20 0.34
▸ PDE10A Q9Y233 2/20 0.33
▸ DYRK1A Q13627 1/20 0.33
▸ AXL P30530 1/20 0.33
▸ NUDT1 P36639 1/20 0.33
▸ KDM4E B2RXH2 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Indole SCHEMBL27650887 0.87 ALDH1A1 (0.46) ALDH1A1HSD17B10TRPA1CA1CA2
Indole SCHEMBL28751322 0.85 ALDH1A1 (0.44) ALDH1A1HSD17B10TRPA1CA1CA2
Naphthalene SCHEMBL27603917 0.80 ALDH1A1 (0.86) ALDH1A1HSD17B10RIPK1NPC1DYRK1A
Benzo[D]Thiazole SCHEMBL27684561 0.80 ALDH1A1 (0.59) ALDH1A1HSD17B10CA1CA4CA6
Benzo[D]Thiazole SCHEMBL10847268 0.78 — —
Benzo[D]Thiazole SCHEMBL31388426 0.78 — —
Benzo[D]Thiazole SCHEMBL8430 0.78 — —
Benzo[D]Thiazole SCHEMBL900814 0.78 ALDH1A1 (1.00) ALDH1A1HSD17B10RIPK1NPC1DYRK1A
Benzo[D]Thiazole SCHEMBL451685 0.78 — —
Anthracene SCHEMBL357514 0.77 ALDH1A1 (0.79) ALDH1A1HSD17B10RIPK1NPC1PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111892588-B Indole-benzothiazole derivative and preparation method and application thereof 广东工业大学 2022-08-12 — — CN claimed
CN-111892588-A Indole-benzothiazole derivative and preparation method and application thereof 广东工业大学 2020-11-06 — — CN claimed
CN-102372703-A Indole benzothiazole derivative and pharmaceutical use thereof UNIV FUDAN 2012-03-14 — — CN claimed
US-5399690-A Contain at least two nitrile groups, non-wandering EASTMAN KODAK COMPANY (US) 1995-03-21 — — US claimed
CN-111039956-B Organic electroluminescent device and amine compound for organic electroluminescent device 三星显示有限公司 2023-12-15 — — CN disclosed
CN-111892588-B Indole-benzothiazole derivative and preparation method and application thereof 广东工业大学 2022-08-12 — — CN disclosed
CN-111892588-B Indole-benzothiazole derivative and preparation method and application thereof 广东工业大学 2022-08-12 — — CN disclosed
CN-111892588-B Indole-benzothiazole derivative and preparation method and application thereof 广东工业大学 2022-08-12 — — CN disclosed
US-11264573-B2 Organic electroluminescence device and amine compound for organic electroluminescence device SAMSUNG DISPLAY CO., LTD. (KR) 2022-03-01 — — US disclosed
CN-111892588-A Indole-benzothiazole derivative and preparation method and application thereof 广东工业大学 2020-11-06 — — CN disclosed
CN-111892588-A Indole-benzothiazole derivative and preparation method and application thereof 广东工业大学 2020-11-06 — — CN disclosed
CN-111892588-A Indole-benzothiazole derivative and preparation method and application thereof 广东工业大学 2020-11-06 — — CN disclosed
CN-109153913-A Luminescent tetradentate gold (III) compounds for organic light-emitting devices and preparation thereof 香港大学 2019-01-04 — — CN disclosed
CN-109053715-A A kind of copper catalysis series connection cyclization constructs N- thiazoline indoles 山东博苑医药化学有限公司 2018-12-21 — — CN disclosed
CN-102925137-B Method for modifying fluorescent dye probe with folic acid by using diamine as bridge group TIANJIN URBAN CONSTRUCTION COLLEGE (CN) 2014-10-15 — — CN disclosed
CN-102925137-A Method for modifying fluorescent dye probe with folic acid by using diamine as bridge group TIANJIN INST URBAN CONSTR 2013-02-13 — — CN disclosed
CN-102372703-A Indole benzothiazole derivative and pharmaceutical use thereof UNIV FUDAN 2012-03-14 — — CN disclosed
CN-102372703-A Indole benzothiazole derivative and pharmaceutical use thereof UNIV FUDAN 2012-03-14 — — CN disclosed
CN-102372703-A Indole benzothiazole derivative and pharmaceutical use thereof UNIV FUDAN 2012-03-14 — — CN disclosed
WO-2011044222-A1 ANTIMICROBIAL COMPOUNDS SHAW INTELLECTUAL PROPERTY HOLDINGS, INC. (US) 2011-04-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11264573-B2 Organic electroluminescence device and amine compound for organic electroluminescence device L1CAM, CHRM1, OPRM1 ALDH1A1 197/4885HSD17B10 4345/4885TRPA1 189/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.