Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | JAK1 | P23458 | 5/20 | 0.37 |
| ▸ | TYK2 | P29597 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16479566 | 1.00 | GBA1 (0.40) | GBA1NPY5RADRA2AJAK2JAK1 | |
| SCHEMBL2841819 | 0.91 | — | — | |
| SCHEMBL16420722 | 0.83 | GBA1 (0.40) | GBA1NPY5RADRA2AJAK2JAK1 | |
| SCHEMBL8260964 | 0.83 | MEN1 (0.40) | GBA1NPY5RADRA2AJAK2JAK1 | |
| SCHEMBL8391559 | 0.82 | ADH1B (0.41) | GBA1NPY5RADRA2AJAK2JAK1 | |
| SCHEMBL5783979 | 0.82 | ADH1B (0.41) | GBA1NPY5RADRA2AJAK2JAK1 | |
| SCHEMBL16479552 | 0.81 | CA2 (0.42) | GBA1MEN1ALDH1A1CYP2C9KMT2A | |
| SCHEMBL22527341 | 0.81 | CYP2D6 (0.39) | GBA1NPY5RADRA2AJAK2JAK1 | |
| SCHEMBL16479531 | 0.81 | CA2 (0.42) | GBA1MEN1ALDH1A1CYP2C9KMT2A | |
| SCHEMBL1542985 | 0.81 | GBA1 (0.39) | GBA1NPY5RADRA2AJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133128-B2 | Pyrazole derivatives as cannabinoid receptor 1 antagonists | RESEARCH TRIANGLE INSTITUTE (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140107157-A1 | PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | RESEARCH TRIANGLE INSTITUTE (US) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107157-A1 | PYRAZOLE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | CNR1, CNR2, GPR119 | GBA1 2518/4885NPY5R 71/4885ADRA2A 319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.