Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 19/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 11/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4877460 | 0.81 | DRD3 (0.39) | DRD3KCNH2HRH1DRD2CHRM1 | |
| SCHEMBL13895695 | 0.79 | DRD3 (0.39) | DRD3KCNH2HRH1DRD2 | |
| SCHEMBL8021753 | 0.73 | IMPDH2 (0.39) | — | |
| SCHEMBL17725475 | 0.70 | DRD3 (0.59) | DRD3KCNH2HRH1DRD2CHRM1 | |
| SCHEMBL17713118 | 0.70 | DRD3 (0.47) | DRD3KCNH2HRH1DRD2CHRM1 | |
| SCHEMBL25436203 | 0.68 | DRD3 (0.31) | DRD3KCNH2DRD2CHRM1CHRM3 | |
| SCHEMBL17713219 | 0.67 | DRD3 (0.49) | DRD3KCNH2HRH1DRD2CHRM1 | |
| SCHEMBL12671303 | 0.67 | DRD2 (0.36) | DRD3KCNH2DRD2CYP2D6 | |
| SCHEMBL13844412 | 0.65 | BRD4 (0.37) | — | |
| SCHEMBL15026023 | 0.63 | HSD11B1 (0.36) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629141-B2 | Spiro-oxindole MDM2 antagonists | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-01-14 | — | — | US | disclosed |