Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 16/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.51 |
| ▸ | PRKACA | P17612 | 5/20 | 0.49 |
| ▸ | PRKACG | P22612 | 5/20 | 0.49 |
| ▸ | PRKACB | P22694 | 5/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23384852 | 0.94 | ROCK2 (0.50) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL1648864 | 0.92 | ROCK2 (0.62) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL1649817 | 0.86 | ROCK2 (0.54) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL1649577 | 0.79 | CLK1 (0.75) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL23384845 | 0.78 | ROCK1 (0.52) | ROCK2ROCK1 | |
| SCHEMBL1648756 | 0.78 | AURKA (0.63) | ROCK2ROCK1PRKACA | |
| SCHEMBL23384847 | 0.77 | ROCK2 (0.50) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL23385059 | 0.76 | ROCK2 (0.45) | ROCK2ROCK1 | |
| SCHEMBL1648234 | 0.76 | ROCK2 (0.65) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL25045772 | 0.76 | ROCK2 (0.39) | ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |
| WO-2011050245-A1 | BICYCLIC HETEROARYLS AS KINASE INHIBITORS | FENG YANGBO (US) | 2011-04-28 | — | — | WO | disclosed |