Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.70 |
| ▸ | MET | P08581 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.58 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648582 | 0.88 | MEN1 (0.78) | MEN1KMT2ASGMS2METLRRK2 | |
| SCHEMBL875474 | 0.84 | SGMS2 (1.00) | MEN1KMT2ASGMS2GAAALDH1A1 | |
| SCHEMBL14428116 | 0.82 | SGMS2 (0.75) | MEN1KMT2ASGMS2GAAALDH1A1 | |
| SCHEMBL16266125 | 0.82 | MEN1 (0.69) | MEN1KMT2AGAAALDH1A1NR1H4 | |
| SCHEMBL1650152 | 0.82 | LRRK2 (0.77) | MEN1KMT2ASGMS2METGAA | |
| SCHEMBL16266096 | 0.81 | MEN1 (0.67) | MEN1KMT2AMETALDH1A1KCNK3 | |
| SCHEMBL28652995 | 0.79 | MEN1 (0.65) | MEN1KMT2ASGMS2GAAALDH1A1 | |
| SCHEMBL30575480 | 0.79 | MEN1 (0.65) | MEN1KMT2ASGMS2GAAALDH1A1 | |
| SCHEMBL14372385 | 0.78 | SGMS2 (0.69) | MEN1KMT2ASGMS2GAAALDH1A1 | |
| SCHEMBL8203327 | 0.78 | SGMS2 (0.82) | MEN1KMT2ASGMS2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | claimed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | claimed |