Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.82 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | PPIA | P62937 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875474 | 0.90 | SGMS2 (1.00) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL8205171 | 0.88 | SGMS2 (0.76) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL8206693 | 0.86 | PPIA (0.61) | SGMS2GAAMEN1KMT2APPIA | |
| SCHEMBL3814319 | 0.85 | SGMS2 (0.80) | SGMS2GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL17551817 | 0.83 | SGMS2 (0.85) | SGMS2 | |
| SCHEMBL27499066 | 0.83 | SGMS2 (0.84) | SGMS2KMT2AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL7345966 | 0.82 | GCK (0.72) | SGMS2GAAMEN1KMT2ANPC1 | |
| SCHEMBL8503911 | 0.82 | SGMS2 (0.54) | SGMS2GAAMEN1KMT2APPIA | |
| SCHEMBL28377300 | 0.80 | SGMS2 (0.63) | SGMS2GAAMEN1KMT2ARAB9A | |
| SCHEMBL7773796 | 0.80 | SGMS2 (0.60) | SGMS2GAAMEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136969-A | PROTEIN KINASE INHIBITORS; 4-HYDROXYBENZOIC ACID 3-(4-(4-FLUOROBENZOYLOXY)-BENZOYLAMINO)-AZEPAN-4-YL ESTER | HOFFMANN-LA ROCHE INC. (US) | 2000-10-24 | — | — | US | disclosed |
| US-5907038-A | PROTEIN KINASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1999-05-25 | — | — | US | disclosed |
| EP-0836592-A1 | AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002249-A1 | NOVEL AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-01-23 | — | — | WO | disclosed |