Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 7/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 10/20 | 0.51 |
| ▸ | PLG | P00747 | 3/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22755532 | 0.94 | TMPRSS2 (0.63) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| Guanisoquin SCHEMBL2109074 | 0.81 | TMPRSS2 (0.63) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| SCHEMBL1648407 | 0.81 | TMPRSS2 (0.63) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| SCHEMBL8544496 | 0.81 | TMPRSS2 (0.63) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| SCHEMBL12287671 | 0.79 | NOTUM (0.65) | LMNARAB9ANPC1 | |
| Debrisoquin SCHEMBL29390380 | 0.78 | TMPRSS2 (1.00) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| Debrisoquin SCHEMBL309184 | 0.78 | TMPRSS2 (1.00) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| SCHEMBL22755533 | 0.77 | TMPRSS2 (0.47) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| SCHEMBL18966975 | 0.76 | DPP8 (0.56) | RAB9ANPC1 | |
| SCHEMBL17902845 | 0.76 | TMPRSS2 (0.52) | TMPRSS2HTR1AADRA2ACYP2D6MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11459323-B2 | Monocyclic β-lactam compound for treating bacterial infection | MEDSHINE DISCOVERY INC. (CN) | 2022-10-04 | — | — | US | disclosed |
| US-20210115035-A1 | MONOCYCLIC B-LACTAM COMPOUND FOR TREATING BACTERIAL INFECTION | Shenzhen Optimum Biological Technology Co., Ltd (CN) | 2021-04-22 | — | — | US | disclosed |
| EP-3747883-A1 | MONOCYCLIC B-LACTAM COMPOUND FOR TREATING BACTERIAL INFECTION | Medshine Discovery Inc. (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-2311810-A1 | AMIDINE DERIVATIVE | Ajinomoto Co., Inc. (JP) | 2011-04-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11459323-B2 | Monocyclic β-lactam compound for treating bacterial infection | PEPD, COASY, MRPL21 | TMPRSS2 1194/4885HTR1A 4455/4885ADRA2A 1440/4885 |
| US-20210115035-A1 | MONOCYCLIC B-LACTAM COMPOUND FOR TREATING BACTERIAL INFECTION | COASY, BCAT2, PEPD | TMPRSS2 1617/4885HTR1A 4378/4885ADRA2A 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.