Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 9/20 | 0.63 |
| ▸ | HTR1A | P08908 | 1/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | F10 | P00742 | 10/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.48 |
| ▸ | PLG | P00747 | 3/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648407 | 0.81 | TMPRSS2 (0.63) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| Guanisoquin SCHEMBL2109074 | 0.81 | TMPRSS2 (0.63) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| SCHEMBL1648408 | 0.81 | TMPRSS2 (0.63) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| Guanisoquin SCHEMBL121149 | 0.78 | LMNA (0.68) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| Guanisoquin SCHEMBL29801607 | 0.78 | LMNA (0.68) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| Debrisoquin SCHEMBL309184 | 0.78 | TMPRSS2 (1.00) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| Debrisoquin SCHEMBL29390380 | 0.78 | TMPRSS2 (1.00) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| SCHEMBL24891975 | 0.75 | TMPRSS2 (0.80) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| SCHEMBL22755532 | 0.74 | TMPRSS2 (0.63) | TMPRSS2HTR1AADRA2ACYP2D6MAOA | |
| Debrisoquin SCHEMBL29711278 | 0.74 | LMNA (1.00) | TMPRSS2HTR1AADRA2ACYP2D6MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846115-A1 | NEW CYCLIC GUANIDINES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS | Roche Diagnostics GmbH (DE) | 1998-06-10 | — | — | EP | disclosed |
| WO-1997008165-A1 | NEW CYCLIC GUANIDINES, PROCESS FOR PREPARING THE SAME AND MEDICAMENTS | BOEHRINGER MANNHEIM GMBH (DE) | 1997-03-06 | — | — | WO | disclosed |