SCHEMBL16484264

SCHEMBL16484264

c1ccc(-c2cccc(-n3c4cccnc4c4c3ccc3c5ccc6c(c7ncccc7n6-c6cccc(-c7ccccn7)c6)c5n(-c5ccccc5)c34)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 12/20 0.41
HTR1A P08908 1/20 0.40
HTR7 P34969 1/20 0.40
DHFR P00374 1/20 0.34
MCL1 Q07820 2/20 0.33
MAPK14 Q16539 1/20 0.32
CYP2A6 P11509 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16484266 0.94 HTR1A (0.38) GRM5HTR1AHTR7DHFRMCL1
SCHEMBL17109006 0.89 GRM5 (0.42) GRM5HTR1AHTR7DHFRMCL1
SCHEMBL17108972 0.87 GRM5 (0.41) GRM5HTR1AHTR7DHFR
SCHEMBL21453997 0.87 L3MBTL1 (0.42) GRM5
SCHEMBL17108991 0.86 GRM5 (0.40) GRM5HTR1AHTR7DHFRCYP2A6
SCHEMBL17175216 0.82 GRM5 (0.44) GRM5HTR1AHTR7DHFRCYP2A6
SCHEMBL17109002 0.82 NPC1 (0.33)
SCHEMBL9955519 0.81 HTR1A (0.43) GRM5HTR1AHTR7DHFRMCL1
SCHEMBL17248289 0.81 HTR1A (0.47) GRM5HTR1AHTR7DHFR
SCHEMBL17109004 0.80 HTR1A (0.33) GRM5HTR1AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9960364-B2 Ladder compound, and organic electroluminescent element using same IDEMITSU KOSAN CO., LTD. (JP) 2018-05-01 US disclosed
US-9960364-B2 Ladder compound, and organic electroluminescent element using same IDEMITSU KOSAN CO., LTD. (JP) 2018-05-01 US disclosed
US-20150270496-A1 LADDER COMPOUND, AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME IDEMIITSU KOSAN CO., LTD. (JP) 2015-09-24 US disclosed
US-20150270496-A1 LADDER COMPOUND, AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME IDEMIITSU KOSAN CO., LTD. (JP) 2015-09-24 US disclosed
WO-2014057684-A1 LADDER COMPOUND, AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME 出光興産株式会社 (JP) 2014-04-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150270496-A1 LADDER COMPOUND, AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME YBX1, ATXN2L, ATXN2 GRM5 2345/4885HTR1A 1317/4885HTR7 2019/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.