Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16465401 | 0.88 | P2RY12 (0.41) | NPC1SMN1; SMN2KDM4EALDH1A1GAA | |
| SCHEMBL27617565 | 0.86 | MAOB (0.46) | NPC1SMN1; SMN2ALDH1A1RAB9AOPRD1 | |
| SCHEMBL542709 | 0.86 | GRIN2B (0.52) | NPC1SMN1; SMN2KDM4EGAARAB9A | |
| SCHEMBL12735949 | 0.83 | SMN1; SMN2 (0.49) | NPC1SMN1; SMN2RAB9AOPRD1MEN1 | |
| SCHEMBL3037782 | 0.83 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL542683 | 0.83 | MEN1 (0.58) | NPC1SMN1; SMN2ALDH1A1RAB9AMEN1 | |
| SCHEMBL27694192 | 0.83 | MEN1 (0.50) | NPC1SMN1; SMN2KDM4EGAARAB9A | |
| Hydrochloric Acid SCHEMBL4678485 | 0.82 | GRIN2B (0.53) | SMN1; SMN2ALDH1A1GAAHPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL1532757 | 0.82 | SMN1; SMN2 (0.48) | NPC1SMN1; SMN2HPGDRAB9AOPRD1 | |
| SCHEMBL14653324 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1GAAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1976904-A | Pyridazin-3 (2H) -one derivatives and their use as PDE4 inhibitors | ALMIRALL LAB (ES) | 2007-06-06 | — | — | CN | claimed |
| EP-2906543-B1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | UNIV ASTON (GB) | 2019-01-02 | — | — | EP | disclosed |
| EP-2906543-B1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | UNIV ASTON (GB) | 2019-01-02 | — | — | EP | disclosed |
| US-9656978-B2 | Acylpiperazines as inhibitors of transglutaminase and their use in medicine | ASTON UNIVERSITY (GB) | 2017-05-23 | — | — | US | disclosed |
| US-9656978-B2 | Acylpiperazines as inhibitors of transglutaminase and their use in medicine | ASTON UNIVERSITY (GB) | 2017-05-23 | — | — | US | disclosed |
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ASTON UNIVERSITY (GB) | 2015-09-17 | — | — | US | disclosed |
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ASTON UNIVERSITY (GB) | 2015-09-17 | — | — | US | disclosed |
| WO-2014057266-A1 | ACYLPIPERAZINES AS INHIBITORS OF TRANSGLUTAMINASE AND THEIR USE IN MEDICINE | ASTON UNIVERSITY (GB) | 2014-04-17 | — | — | WO | disclosed |
| CN-1976904-A | Pyridazin-3 (2H) -one derivatives and their use as PDE4 inhibitors | ALMIRALL LAB (ES) | 2007-06-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259310-A1 | Acylpiperazines as Inhibitors of Transglutaminase and Their Use in Medicine | ENPEP, ENPP2, MMP17 | NPC1 1326/4885SMN1; SMN2 3124/4885KDM4E 3109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.