Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 6/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.40 |
| ▸ | KLK1 | P06870 | 2/20 | 0.40 |
| ▸ | CHKA | P35790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL28052879 | 0.89 | CHRM3 (0.47) | CHRM3SYKATMACKR3FAAH | |
| SCHEMBL14622529 | 0.85 | CHRM3 (0.46) | CHRM3KDM5CKDM4C | |
| SCHEMBL23013506 | 0.83 | ALDH1A1 (0.57) | ACKR3FAAHKLKB1KLK1 | |
| SCHEMBL16486820 | 0.83 | FAAH (0.47) | ATMACKR3FAAHCHKA | |
| SCHEMBL28248650 | 0.83 | KLKB1 (0.46) | ATMACKR3FAAHKLKB1KLK1 | |
| SCHEMBL1512308 | 0.80 | CHRM3 (0.72) | CHRM3 | |
| SCHEMBL23013170 | 0.79 | KLKB1 (0.53) | ATMACKR3FAAHKLKB1KLK1 | |
| SCHEMBL3569140 | 0.79 | CHKA (0.60) | CHRM3SYKATMCHKA | |
| SCHEMBL16486773 | 0.78 | ACKR3 (0.46) | ATMACKR3FAAH | |
| SCHEMBL29390664 | 0.78 | ACKR3 (0.46) | ATMACKR3FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153724-A1 | Inhibitors Of Plasma Kallikrein | KALVISTA PHARMACEUTICALS LTD (GB) | 2022-05-19 | — | — | US | disclosed |
| US-11242333-B2 | Inhibitors of plasma kallikrein | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2022-02-08 | — | — | US | disclosed |
| US-20190152950-A1 | Inhibitors Of Plasma Kallikrein | KALVISTA PHARMACEUTICALS LTD (GB) | 2019-05-23 | — | — | US | disclosed |
| US-10221161-B2 | Inhibitors of plasma kallikrein | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2019-03-05 | — | — | US | disclosed |
| CN-105683179-B | inhibitors of plasma kallikrein | 卡尔维斯塔制药有限公司 | 2018-10-26 | — | — | CN | disclosed |
| EP-3033336-B1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2018-05-30 | — | — | EP | disclosed |
| EP-3033336-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2016-06-22 | — | — | EP | disclosed |
| US-20160168123-A1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-16 | — | — | US | disclosed |
| CN-105683179-A | Inhibitors of plasma kallikrein | 卡尔维斯塔制药有限公司 | 2016-06-15 | — | — | CN | disclosed |
| WO-2015022546-A1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2015-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152950-A1 | Inhibitors Of Plasma Kallikrein | KLKB1, SERPINB1, KLK5 | CHRM3 1359/4885SYK 2494/4885ATM 2180/4885 |
| US-20220153724-A1 | Inhibitors Of Plasma Kallikrein | KLKB1, SERPINB1, KLK5 | CHRM3 1359/4885SYK 2494/4885ATM 2180/4885 |
| US-11242333-B2 | Inhibitors of plasma kallikrein | KLKB1, SERPINB1, KLK5 | CHRM3 1359/4885SYK 2494/4885ATM 2180/4885 |
| US-10221161-B2 | Inhibitors of plasma kallikrein | KLKB1, SERPINB1, KLK5 | CHRM3 1359/4885SYK 2494/4885ATM 2180/4885 |
| US-20160168123-A1 | INHIBITORS OF PLASMA KALLIKREIN | KLKB1, SERPINB1, KLK5 | CHRM3 1359/4885SYK 2494/4885ATM 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.