Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 3/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | MME | P08473 | 8/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 7/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27800230 | 0.90 | FDFT1 (0.54) | MMP12MMP2MMP9MMP13MMP14 | |
| SCHEMBL18019606 | 0.90 | FDFT1 (0.54) | MMP12MMP2MMP9MMP13MMP14 | |
| SCHEMBL1073143 | 0.89 | TSHR (0.68) | TSHR | |
| SCHEMBL264775 | 0.89 | TSHR (0.68) | TSHR | |
| SCHEMBL12670558 | 0.89 | TSHR (0.68) | TSHR | |
| SCHEMBL473576 | 0.89 | TSHR (0.68) | TSHR | |
| Dimethylaminoethanol SCHEMBL125407 | 0.87 | MMP12 (0.47) | MMP12MMP2MMP9MMP13MMP14 | |
| Phosphine SCHEMBL27480220 | 0.87 | TSHR (0.66) | TSHR | |
| SCHEMBL25181550 | 0.81 | TSHR (0.50) | TSHRFFAR1 | |
| SCHEMBL4020585 | 0.81 | MME (0.63) | MMEACECPA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10189786-B2 | Antibacterial compounds | DUKE UNIVERSITY (US) | 2019-01-29 | — | — | US | disclosed |
| US-10189786-B2 | Antibacterial compounds | DUKE UNIVERSITY (US) | 2019-01-29 | — | — | US | disclosed |
| US-20160200673-A1 | Antibacterial Compounds | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| US-20160200673-A1 | Antibacterial Compounds | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| US-20160200673-A1 | Antibacterial Compounds | DUKE UNIVERSITY | 2016-07-14 | — | — | US | disclosed |
| WO-2015024011-A2 | ANTIBACTERIAL COMPOUNDS | DUKE UNIVERSITY (US) | 2015-02-19 | — | — | WO | disclosed |
| WO-2015024021-A2 | ANTIBACTERIAL COMPOUNDS | DUKE UNIVERSITY (US) | 2015-02-19 | — | — | WO | disclosed |
| WO-2015024021-A2 | ANTIBACTERIAL COMPOUNDS | DUKE UNIVERSITY (US) | 2015-02-19 | — | — | WO | disclosed |
| WO-2015024011-A2 | ANTIBACTERIAL COMPOUNDS | DUKE UNIVERSITY (US) | 2015-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10189786-B2 | Antibacterial compounds | Q6ZSR9, MRPL21, XDH | MMP12 821/4885MMP2 1097/4885MMP9 765/4885 |
| US-20160200673-A1 | Antibacterial Compounds | Q6ZSR9, MRPL21, XDH | MMP12 821/4885MMP2 1097/4885MMP9 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.