SCHEMBL1648718

SCHEMBL1648718

O=C(O)CC(Cl)C(=O)OC(=O)C(Cl)CC(=O)O

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SLC22A6 Q4U2R8 1/20 0.39
TDP1 Q9NUW8 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.36
MAPT P10636 1/20 0.34
ALOX15 P16050 1/20 0.34
LMNA P02545 3/20 0.33
GABRR1 P24046 2/20 0.33
TSHR P16473 2/20 0.32
FFAR3 O14843 1/20 0.32
FOLH1 Q04609 1/20 0.31
CYP2C9 P11712 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3399219 0.84 HCAR2 (0.33) SLC22A6TDP1SMN1; SMN2
SCHEMBL8307598 0.83 ALDH1A1 (0.41) SLC22A6TDP1SMN1; SMN2MAPTALOX15
SCHEMBL5915068 0.82 SLC22A6 (0.38) SLC22A6TDP1SMN1; SMN2MAPTALOX15
SCHEMBL1480202 0.80 KMT2A (0.37) SLC22A6TDP1SMN1; SMN2MAPTALOX15
SCHEMBL6057628 0.80 KMT2A (0.37) SLC22A6TDP1SMN1; SMN2MAPTALOX15
SCHEMBL27476095 0.80 SLC22A6 (0.36) SLC22A6TDP1SMN1; SMN2MAPTALOX15
SCHEMBL11219831 0.77 ALDH1A1 (0.42) TDP1LMNATSHR
SCHEMBL8625996 0.75 FOLH1 (0.44) MAPTLMNAFOLH1
SCHEMBL5246516 0.75 SLC22A6 (0.32) SLC22A6TDP1SMN1; SMN2
SCHEMBL640316 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116643042-A Thrombomodulin Chemiluminescence Detection Kit 上海太阳生物技术有限公司 2023-08-25 CN claimed
CN-116643042-A Thrombomodulin Chemiluminescence Detection Kit 上海太阳生物技术有限公司 2023-08-25 CN disclosed
US-8491929-B2 Bioadhesive polymers VAUNNEX INC. (US) 2013-07-23 US disclosed
US-20110086095-A1 Bioadhesive Polymers Spherics, Inc (MA) 2011-04-14 US disclosed
US-20100316712-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS COMBINATORX, INCORPORATED (US) 2010-12-16 US disclosed
US-7784919-B2 Methods for improving flow through fluidic channels LEXMARK INTERNATIONAL, INC. (US) 2010-08-31 US disclosed
EP-2063867-A2 PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS Combinatorx, Incorporated (US) 2009-06-03 EP disclosed
US-20080299204-A1 Dosage forms for movement disorder treatment SPHERICS, INC. (US) 2008-12-04 US disclosed
WO-2008079404-A2 PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS COMBINATORX, INCORPORATED (US) 2008-07-03 WO disclosed
US-20080131492-A1 Dosage forms for movement disorder treatment SPHERICS, INC. (US) 2008-06-05 US disclosed
EP-1901720-A2 IMPROVED DOSAGE FORMS FOR MOVEMENT DISORDER TREATMENT Spherics, Inc. (US) 2008-03-26 EP disclosed
WO-2008002471-A2 EROSION-STABILIZED BIOADHESIVE POLYMERS FUNCTIONALIZED OR BLENDED WITH CATECHOL AND DERIVATIVES THEREOF SPHERICS, INC. (US) 2008-01-03 WO disclosed
US-20070148238-A1 Dosage forms for movement disorder treatment SPHERICS, INC. (US) 2007-06-28 US disclosed
US-20070076058-A1 Methods for improving flow through fluidic channels LEXMARK INTERNATIONAL, INC. 2007-04-05 US disclosed
WO-2007002318-A2 BIOADHESIVE POLYMERS SPHERICS, INC. (US) 2007-01-04 WO disclosed
WO-2007002516-A2 IMPROVED DOSAGE FORMS FOR MOVEMENT DISORDER TREATMENT SPHERICS, INC. (US) 2007-01-04 WO disclosed
US-20070003621-A1 Dosage forms for movement disorder treatment SPHERICS, INC. (US) 2007-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110086095-A1 Bioadhesive Polymers CD44, EPCAM, ABCG2 SLC22A6 701/4885TDP1 2516/4885SMN1; SMN2 2825/4885
US-20100316712-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF PARKINSON'S DISEASE AND RELATED DISORDERS PARK7, SNCA, COMT SLC22A6 1589/4885TDP1 402/4885SMN1; SMN2 6/4885
US-20070148238-A1 Dosage forms for movement disorder treatment PARK7, SNCA, HTT SLC22A6 537/4885TDP1 416/4885SMN1; SMN2 6/4885
US-20080131492-A1 Dosage forms for movement disorder treatment PARK7, SNCA, HTT SLC22A6 537/4885TDP1 416/4885SMN1; SMN2 6/4885
US-20070003621-A1 Dosage forms for movement disorder treatment PARK7, SNCA, HTT SLC22A6 537/4885TDP1 416/4885SMN1; SMN2 6/4885
US-20080299204-A1 Dosage forms for movement disorder treatment PARK7, SNCA, HTT SLC22A6 537/4885TDP1 416/4885SMN1; SMN2 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.