Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648368 | 0.81 | IMPDH2 (0.43) | IMPDH2AAK1ROCK2ROCK1IMPDH1 | |
| SCHEMBL1649411 | 0.81 | KMT2A (0.43) | KMT2AALDH1A1L3MBTL1KEAP1NPC1 | |
| SCHEMBL1649969 | 0.79 | KMT2A (0.35) | KMT2AALDH1A1L3MBTL1KEAP1NPC1 | |
| SCHEMBL1647744 | 0.77 | KMT2A (0.47) | KMT2APOLBALDH1A1EDNRANPC1 | |
| SCHEMBL18801288 | 0.76 | IMPDH2 (0.40) | IMPDH2KMT2APOLBAAK1ROCK2 | |
| SCHEMBL1648310 | 0.76 | KMT2A (0.35) | KMT2AALDH1A1L3MBTL1KEAP1NPC1 | |
| SCHEMBL1648257 | 0.75 | EDNRA (0.51) | IMPDH2KMT2APOLBAAK1ALDH1A1 | |
| SCHEMBL1648935 | 0.75 | KMT2A (0.41) | KMT2AALDH1A1L3MBTL1KEAP1NPC1 | |
| SCHEMBL18784237 | 0.74 | IMPDH2 (0.42) | IMPDH2AAK1ROCK2ROCK1 | |
| SCHEMBL18784238 | 0.74 | AAK1 (0.41) | IMPDH2AAK1KEAP1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen Corporation (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |