Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 9/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801288 | 0.89 | IMPDH2 (0.40) | IMPDH2AAK1ROCK2ROCK1 | |
| SCHEMBL18784238 | 0.84 | AAK1 (0.41) | IMPDH2AAK1ROCK2ROCK1 | |
| SCHEMBL1648368 | 0.82 | IMPDH2 (0.43) | IMPDH2AAK1ROCK2ROCK1 | |
| SCHEMBL1648147 | 0.78 | IMPDH2 (0.42) | IMPDH2AAK1ROCK2ROCK1 | |
| SCHEMBL1648736 | 0.74 | IMPDH2 (0.37) | IMPDH2AAK1ROCK2ROCK1 | |
| SCHEMBL1648257 | 0.68 | EDNRA (0.51) | IMPDH2AAK1 | |
| SCHEMBL18784217 | 0.68 | GBA1 (0.34) | — | |
| SCHEMBL1649016 | 0.66 | METAP2 (0.47) | — | |
| SCHEMBL1647744 | 0.66 | KMT2A (0.47) | — | |
| SCHEMBL15741596 | 0.64 | IMPDH2 (0.74) | IMPDH2AAK1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | claimed |