Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647829 | 0.87 | TSHR (0.44) | KMT2AALDH1A1L3MBTL1HSD11B1NPC1 | |
| SCHEMBL1649411 | 0.83 | KMT2A (0.43) | KMT2AALDH1A1L3MBTL1HSD11B1KEAP1 | |
| SCHEMBL1648993 | 0.81 | KMT2A (0.42) | KMT2AALDH1A1L3MBTL1HSD11B1KEAP1 | |
| SCHEMBL1648084 | 0.79 | ALDH1A1 (0.43) | KMT2AALDH1A1L3MBTL1HSD11B1KEAP1 | |
| SCHEMBL1648310 | 0.76 | KMT2A (0.35) | KMT2AALDH1A1L3MBTL1HSD11B1KEAP1 | |
| SCHEMBL1648340 | 0.76 | METAP2 (0.50) | KMT2AALDH1A1L3MBTL1HSD11B1KEAP1 | |
| SCHEMBL1649969 | 0.75 | KMT2A (0.35) | KMT2AALDH1A1L3MBTL1HSD11B1KEAP1 | |
| SCHEMBL14717673 | 0.75 | DHODH (0.36) | KMT2AALDH1A1L3MBTL1KEAP1NFE2L2 | |
| SCHEMBL1648736 | 0.75 | IMPDH2 (0.37) | KMT2AALDH1A1L3MBTL1HSD11B1KEAP1 | |
| SCHEMBL1649919 | 0.75 | KEAP1 (0.42) | KMT2AALDH1A1L3MBTL1HSD11B1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen Corporation (US) | 2012-08-15 | — | — | EP | claimed |
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | claimed |