Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 5/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 5/20 | 0.38 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 3/20 | 0.32 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164810 | 0.73 | PRKCI (0.33) | PDPK1PRKCI | |
| SCHEMBL166424 | 0.71 | ALDH1A1 (0.46) | RAB9ATNKSTNKS2PARP1PIM1 | |
| SCHEMBL18701489 | 0.69 | CDC7 (0.41) | PDPK1TNKSTNKS2SCN10ACDC7 | |
| SCHEMBL174383 | 0.69 | PRKCI (0.34) | PRKCI | |
| SCHEMBL166022 | 0.66 | NTRK1 (0.43) | JAK2JAK1TYK2JAK3NTRK3 | |
| SCHEMBL18701503 | 0.66 | PDPK1 (0.38) | PDPK1RAB9APIM1PIM2SCN10A | |
| SCHEMBL161789 | 0.63 | ALDH1A1 (0.49) | PDPK1CDC7DBF4IKBKBCDK2 | |
| SCHEMBL164202 | 0.62 | NPC1 (0.35) | PDPK1RAB9APRKCIMAPK14LRRK2 | |
| SCHEMBL21712605 | 0.61 | CDC7 (0.51) | PDPK1RAB9ASCN10ACDC7DBF4 | |
| SCHEMBL21467158 | 0.61 | PKM (0.59) | TNKSTNKS2PARP1SCN10AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611812-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030894-A1 | THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |