Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 1.00 |
| ▸ | PTGES | O14684 | 5/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | BACE1 | P56817 | 3/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.76 |
| ▸ | MMP9 | P14780 | 3/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.76 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.76 |
| ▸ | MAOA | P21397 | 2/20 | 0.76 |
| ▸ | MAOB | P27338 | 2/20 | 0.76 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933340 | 0.95 | APP (0.91) | APPPTGESMAPTBACE1HDAC3 | |
| SCHEMBL16488003 | 0.90 | APP (1.00) | APPPTGESMAPTBACE1HDAC3 | |
| SCHEMBL16487566 | 0.90 | APP (0.81) | APPPTGESMAPTBACE1HDAC3 | |
| SCHEMBL12253288 | 0.88 | APP (0.91) | APPPTGESMAPTBACE1HDAC3 | |
| Curcumin SCHEMBL250984 | 0.87 | APP (1.00) | APPPTGESMAPTBACE1HDAC3 | |
| Curcumin SCHEMBL17629819 | 0.87 | APP (1.00) | APPPTGESMAPTBACE1HDAC3 | |
| Curcumin SCHEMBL6901740 | 0.87 | APP (1.00) | APPPTGESMAPTBACE1HDAC3 | |
| Curcumin SCHEMBL8440 | 0.87 | APP (1.00) | APPPTGESMAPTBACE1HDAC3 | |
| Curcumin SCHEMBL2804734 | 0.87 | APP (1.00) | APPPTGESMAPTBACE1HDAC3 | |
| Curcumin SCHEMBL8336603 | 0.87 | APP (1.00) | APPPTGESMAPTBACE1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8956589-B2 | Imaging diagnostic agent and extracorporeal diagnostic agent for incurable neurological diseases | SHIGA UNIVERSITY OF MEDICAL SCIENCE (JP) | 2015-02-17 | — | — | US | disclosed |