Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.91 |
| ▸ | MAPT | P10636 | 7/20 | 0.80 |
| ▸ | BACE1 | P56817 | 4/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.80 |
| ▸ | MMP9 | P14780 | 3/20 | 0.80 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.80 |
| ▸ | TSHR | P16473 | 2/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.80 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.80 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.80 |
| ▸ | MAOA | P21397 | 2/20 | 0.80 |
| ▸ | MAOB | P27338 | 2/20 | 0.80 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.80 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.80 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.80 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.80 |
| ▸ | PTGES | O14684 | 2/20 | 0.80 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.80 |
| ▸ | TOP2A | P11388 | 2/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16488002 | 0.95 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| SCHEMBL1376369 | 0.90 | APP (0.80) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL17629819 | 0.89 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL8440 | 0.89 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL17629818 | 0.89 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL8336603 | 0.89 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL250984 | 0.89 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL6901740 | 0.89 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL2804734 | 0.89 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 | |
| Curcumin SCHEMBL29360171 | 0.89 | APP (1.00) | APPMAPTBACE1NFKB1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360068-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2024-10-31 | — | — | US | disclosed |
| US-20230265041-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-08-24 | — | — | US | disclosed |
| US-11608309-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2023-03-21 | — | — | US | disclosed |
| US-20210053905-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-02-25 | — | — | US | disclosed |
| US-10669227-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2020-06-02 | — | — | US | disclosed |
| EP-3206488-B1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | UNIV NEW YORK STATE RES FOUND (US) | 2019-08-21 | — | — | EP | disclosed |
| EP-3206488-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | The Research Foundation Of State University Of New York (US) | 2017-08-23 | — | — | EP | disclosed |
| US-20170158605-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2017-06-08 | — | — | US | disclosed |
| US-9556105-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160031795-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2016-02-04 | — | — | US | disclosed |
| US-9187406-B2 | Curcumin analogues as zinc chelators and their uses | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2015-11-17 | — | — | US | disclosed |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | CHEM-MASTER INTERNATIONAL, INC. | 2012-04-19 | — | — | US | disclosed |
| WO-2010132815-A9 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2010132815-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 2010-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265041-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND TEHIR USES | NFRKB, NFKBIA, NFKB1 | APP 530/4885MAPT 2850/4885BACE1 144/4885 |
| US-20120095051-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | APP 352/4885MAPT 3287/4885BACE1 77/4885 |
| US-10669227-B2 | Curcumin analogues as zinc chelators and their uses | NFKBIA, NFKB1, NFKB2 | APP 352/4885MAPT 3287/4885BACE1 77/4885 |
| US-20170158605-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | APP 352/4885MAPT 3287/4885BACE1 77/4885 |
| US-11608309-B2 | Curcumin analogues as zinc chelators and their uses | NFKBIA, NFKB1, NFKB2 | APP 352/4885MAPT 3287/4885BACE1 77/4885 |
| US-20210053905-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | APP 352/4885MAPT 3287/4885BACE1 77/4885 |
| US-20160031795-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | APP 352/4885MAPT 3287/4885BACE1 77/4885 |
| US-20240360068-A1 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES | NFKBIA, NFKB1, NFKB2 | APP 352/4885MAPT 3287/4885BACE1 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.