Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 5/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.51 |
| ▸ | F2 | P00734 | 4/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | C1S | P09871 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.47 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.44 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.43 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16489292 | 0.85 | PRSS1 (0.46) | PRSS1PRSS2PRSS3F2PLG | |
| SCHEMBL3237371 | 0.82 | TSHR (0.56) | KMT2AALDH1A1 | |
| SCHEMBL8409513 | 0.78 | KMT2A (0.48) | PRSS1PRSS2PRSS3F2PLG | |
| SCHEMBL15289189 | 0.77 | PRSS1 (0.55) | PRSS1PRSS2PRSS3F2PLG | |
| SCHEMBL2338220 | 0.77 | CA2 (0.52) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL11547040 | 0.77 | F10 (0.61) | PRSS1PRSS2PRSS3F2PLG | |
| SCHEMBL8556017 | 0.77 | TSHR (0.58) | PRSS1PRSS2PRSS3F2PLG | |
| SCHEMBL498617 | 0.76 | ALDH1A1 (0.56) | PRSS1PRSS2PRSS3KDM4EALDH1A1 | |
| SCHEMBL2337040 | 0.75 | KMT2A (0.46) | KMT2AALDH1A1 | |
| SCHEMBL1137128 | 0.75 | LMNA (0.47) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266828-B2 | Inhibitors of Furin and other pro-protein convertases | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-02-23 | — | — | US | disclosed |
| US-20150073054-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2015-03-12 | — | — | US | disclosed |
| US-20150051138-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051138-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | FURIN, PREP, PCSK6 | PRSS1 16/4885PRSS2 43/4885PRSS3 64/4885 |
| US-20150073054-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | FURIN, PREP, PCSK6 | PRSS1 16/4885PRSS2 43/4885PRSS3 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.