Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Chlorproethazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.74 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.74 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.74 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.74 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.74 |
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | HTR1A | P08908 | 4/20 | 0.74 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | DRD2 | P14416 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.74 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.74 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorproethazine SCHEMBL149201 | 0.98 | CYP1A2 (0.77) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| Chlorproethazine SCHEMBL29818123 | 0.98 | CYP1A2 (0.77) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| Chlorproethazine SCHEMBL9724486 | 0.96 | LMNA (0.78) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| SCHEMBL142925 | 0.90 | ITGB2 (0.76) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| Hydrochloric Acid SCHEMBL7342890 | 0.89 | ITGB2 (0.74) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| Chlorpromazine SCHEMBL157752 | 0.88 | CYP1A2 (0.95) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| SCHEMBL4247663 | 0.86 | CYP1A2 (0.71) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| Chlorpromazine SCHEMBL29358018 | 0.85 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| Chlorpromazine SCHEMBL8321 | 0.85 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19LMNAHTR1A | |
| Chlorpromazine SCHEMBL29367385 | 0.85 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP2C19LMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |