Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.68 |
| ▸ | HTR6 | P50406 | 5/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16512498 | 0.89 | SIRT6 (0.56) | SIRT6HTR6HRH4MAPTCYP1A2 | |
| SCHEMBL1847175 | 0.81 | SIRT6 (1.00) | SIRT6HTR6MAPTALDH1A1L3MBTL1 | |
| SCHEMBL15722616 | 0.81 | HRH4 (0.63) | SIRT6HTR6HRH4MET | |
| SCHEMBL10323106 | 0.79 | HRH4 (0.59) | SIRT6HTR6HRH4MET | |
| SCHEMBL3147203 | 0.79 | SIRT6 (0.83) | SIRT6HTR6MAPTALDH1A1L3MBTL1 | |
| SCHEMBL16489582 | 0.78 | SIRT6 (0.61) | SIRT6HTR6HRH4MAPTALDH1A1 | |
| SCHEMBL10322813 | 0.77 | HTR6 (0.66) | SIRT6HTR6HRH4ALDH1A1MET | |
| Formaldehyde SCHEMBL27516052 | 0.76 | MAPT (0.52) | SIRT6HTR6MAPTALDH1A1TDP1 | |
| SCHEMBL8560894 | 0.75 | HTR6 (0.55) | SIRT6HTR6MAPTALDH1A1TDP1 | |
| SCHEMBL15740633 | 0.75 | MAPT (0.53) | SIRT6HTR6MAPTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296748-B2 | Pyridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-03-29 | — | — | US | disclosed |
| US-20150246919-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INT (DE) | 2015-09-03 | — | — | US | disclosed |
| WO-2015022332-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | WO | disclosed |
| US-20150051208-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051208-A1 | PYRIDINONES | MKI67, XDH, CDK6 | SIRT6 320/4885HTR6 30/4885HRH4 417/4885 |
| US-20150246919-A1 | PYRIDINONES | MKI67, XDH, CDK6 | SIRT6 320/4885HTR6 30/4885HRH4 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.