Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | PDE6D | O43924 | 2/20 | 0.58 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.58 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | BRD4 | O60885 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16489620 | 0.92 | ALDH1A1 (0.56) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| SCHEMBL16489711 | 0.86 | ALDH1A1 (0.50) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| SCHEMBL16489610 | 0.84 | BRD4 (0.55) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| SCHEMBL16489708 | 0.84 | BRD4 (0.63) | BRD4 | |
| SCHEMBL16489710 | 0.82 | BRD4 (0.64) | BRD4 | |
| SCHEMBL16489604 | 0.82 | ALDH1A1 (0.56) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| SCHEMBL16489655 | 0.80 | BRD4 (0.56) | ALDH1A1TP53BRD4MAPTSMN1; SMN2 | |
| SCHEMBL16489700 | 0.80 | BRD4 (0.53) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| SCHEMBL16489613 | 0.80 | BRD4 (0.55) | ALDH1A1PDE6DALDH2ALDH3A1TP53 | |
| SCHEMBL16489647 | 0.80 | BRD4 (0.53) | ALDH1A1PDE6DALDH2ALDH3A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296748-B2 | Pyridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-03-29 | — | — | US | disclosed |
| US-20150246919-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INT (DE) | 2015-09-03 | — | — | US | disclosed |
| US-20150051208-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051208-A1 | PYRIDINONES | MKI67, XDH, CDK6 | ALDH1A1 545/4885PDE6D 297/4885ALDH2 1425/4885 |
| US-20150246919-A1 | PYRIDINONES | MKI67, XDH, CDK6 | ALDH1A1 545/4885PDE6D 297/4885ALDH2 1425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.