SCHEMBL1649

SCHEMBL1649

O=C(Cl)c1ccc(F)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.62
CES1 P23141 1/20 0.62
CA1 P00915 2/20 0.56
CA2 P00918 2/20 0.56
BCL2L1 Q07817 1/20 0.52
BAD Q92934 1/20 0.52
PTPN1 P18031 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
ALDH1A1 P00352 1/20 0.48
LTA4H P09960 1/20 0.48
TNFRSF1A P19438 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
KCNQ3 O43525 1/20 0.44
KCNQ2 O43526 1/20 0.44
KCNE1 P15382 1/20 0.44
KCNQ1 P51787 1/20 0.44
BACE1 P56817 1/20 0.44
HTR7 P34969 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL630595 0.97 CES2 (0.59) CES2CES1CA1CA2BCL2L1
SCHEMBL2717519 0.93 BCL2L1 (0.64) CES2CES1CA1CA2BCL2L1
Ethylene SCHEMBL27657103 0.93 CES2 (0.54) CES2CES1CA1CA2BCL2L1
SCHEMBL8700603 0.91 ALDH1A1 (0.53) CES2CES1CA1CA2BCL2L1
SCHEMBL5745794 0.89 CES2 (0.50) CES2CES1CA1CA2BCL2L1
SCHEMBL28447799 0.87 PARP10 (0.48) CES2CES1CA1CA2BCL2L1
SCHEMBL20587670 0.85 ALDH1A1 (0.59) CES2CES1CA1CA2ALDH1A1
SCHEMBL68148 0.85 ALDH1A1 (0.59) CES2CES1CA1CA2ALDH1A1
SCHEMBL29369971 0.84 CES2 (0.44) CES2CES1CA1CA2BCL2L1
SCHEMBL11196376 0.83 ALDH1A1 (0.47) CES2CES1CA1CA2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8356 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743438-A1 AN IMPROVED PROCESS FOR THE PREPARATION OF BENZONITRILE COMPOUNDS FROM THE BENZOTRICHLORIDE COMPOUNDS Aarti Industries Limited (IN) 2026-05-20 EP claimed
EP-4724442-A1 AGONISM-ANTAGONISM IN ENDOSOMAL TLRS BY MODULATING CHEMICAL FEATURES IN 8-OXOPURINE: PROCESS FOR PREPARATION AND APPLICATION THEREOF Council of Scientific and Industrial Research (IN) 2026-04-15 EP claimed
US-12528777-B2 Quinazolinones derivatives for treatment of non-alcoholic fatty liver disease, preparation and use thereof COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2026-01-20 US claimed
EP-4665705-A1 A PROCESSES FOR THE PREPARATION OF BENZONITRILE COMPOUNDS FROM THE CORRESPONDING BENZOTRICHLORIDE COMPOUNDS Aarti Industries Limited (IN) 2025-12-24 EP claimed
US-20250297056-A1 METHOD FOR PRODUCING POLYETHERKETONEKETONE ARKEMA FRANCE (FR) 2025-09-25 US claimed
CN-116284203-B Tanshinone IIA C-1 position esterified derivative and preparation method and application thereof 郑州大学 2025-06-10 CN claimed
CN-119874563-A Cyclic biperoxides, synthesis method and application thereof in preparation of alkyl difunctional compounds 西安交通大学 2025-04-25 CN claimed
CN-118571634-B Preparation process of nanocrystalline iron core containing flexible epoxy resin for high-frequency transformer 曼特(广州)磁性器件有限公司 2025-04-11 CN claimed
CN-119798229-A Preparation method of imatinib dimer 中国食品药品检定研究院 2025-04-11 CN claimed
CN-119798108-A Preparation method of inner-ring profenofos and intermediate thereof in micro-channel 福州大学 2025-04-11 CN claimed
EP-0440329-A1 S-substituted carbonyl substituted betathioacrylamide biocides and fungicides ROHM AND HAAS COMPANY (US) 1991-08-07 EP claimed
CN-1030418-A Setaria-semen glycines spermine ester and glycoside MERRELL DOW PHARMA (US) 1989-01-18 CN claimed
EP-0297534-A2 Castanospermine esters and glycosides MERRELL DOW PHARMACEUTICALS INC. (US) 1989-01-04 EP claimed
US-4710562-A Stabilizing polyaryletherketones AMOCO CORPORATION (US) 1987-12-01 US claimed
US-4668830-A Process for the preparation of compounds containing a difluoromethylene or trifluoromethyl group RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1987-05-26 US claimed
EP-0221149-A1 BLOCK POLYMERS CONTAINING A POLY(ARYL ETHER KETONE) AND METHODS FOR THEIR PRODUCTION AMOCO CORPORATION (US) 1987-05-13 EP claimed
US-4652654-A Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazole acetic acid RAVIZZA SPA (IT) 1987-03-24 US claimed
WO-1986006389-A1 BLOCK POLYMERS CONTAINING A POLY(ARYL ETHER KETONE) AND METHODS FOR THEIR PRODUCTION AMOCO CORPORATION (US) 1986-11-06 WO claimed
EP-0182061-A1 New process for preparing 2(4-fluorophenyl) alpha methyl-5-benzoxazole acetic acid RAVIZZA S.p.A. (IT) 1986-05-28 EP claimed
EP-0069598-B1 PREPARATION OF AROMATIC KETONES RAYCHEM CORPORATION (a California corporation) (US) 1984-12-19 EP claimed