Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 2/20 | 0.46 |
| ▸ | USP5 | P45974 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27713628 | 0.89 | MMP3 (0.43) | MMP3USP5HSD11B1ALDH1A1RAB9A | |
| SCHEMBL2156536 | 0.89 | MMP3 (0.51) | MMP3USP5HSD11B1POLBMAPT | |
| SCHEMBL27693768 | 0.85 | MAPT (0.47) | POLBMAPTALDH1A1LMNASIGMAR1 | |
| SCHEMBL2155627 | 0.84 | MMP3 (0.48) | MMP3USP5HSD11B1POLBMAPT | |
| SCHEMBL27693729 | 0.81 | DRD2 (0.41) | MMP3USP5POLBMAPTALDH1A1 | |
| SCHEMBL2156531 | 0.81 | MMP3 (0.41) | MMP3USP5HSD11B1POLBMAPT | |
| SCHEMBL16493551 | 0.80 | MMP3 (0.43) | MMP3USP5HSD11B1POLBMAPT | |
| SCHEMBL27693734 | 0.79 | KMT2A (0.44) | MAPTALDH1A1 | |
| SCHEMBL2154896 | 0.78 | MMP3 (0.48) | MMP3USP5ALDH1A1RAB9AKDM4E | |
| SCHEMBL16493563 | 0.77 | MMP3 (0.46) | MMP3USP5HSD11B1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101124213-A | Sulfonylamino cyclic derivatives and uses thereof | SERONO LAB (CH) | 2008-02-13 | — | — | CN | claimed |
| EP-1828160-B1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | MERCK SERONO SA (CH) | 2011-12-14 | — | — | EP | disclosed |
| CN-101124213-A | Sulfonylamino cyclic derivatives and uses thereof | SERONO LAB (CH) | 2008-02-13 | — | — | CN | disclosed |