Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.41 |
| ▸ | CLK3 | P49761 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16494907 | 0.88 | ROCK2 (0.45) | VCPCLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL16494409 | 0.86 | CLK1 (0.40) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL14839724 | 0.86 | VCP (0.42) | VCPLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL2598738 | 0.85 | LMNA (0.41) | VCPLMNACLK1CLK2DYRK1A | |
| SCHEMBL16494287 | 0.85 | VCP (0.41) | VCPLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL16494886 | 0.84 | VCP (0.41) | VCPLMNAMAPTALDH1A1KDM4E | |
| SCHEMBL16494310 | 0.84 | CLK2 (0.45) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL16494099 | 0.82 | CLK2 (0.43) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL16494536 | 0.82 | CLK1 (0.43) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL12185454 | 0.79 | CLK1 (0.53) | LMNACLK1CLK2DYRK1ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |