Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alizapride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 12/20 | 0.68 |
| ▸ | DRD3 | P35462 | 7/20 | 0.68 |
| ▸ | DRD4 | P21917 | 6/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | CA4 | P22748 | 1/20 | 0.60 |
| ▸ | CA6 | P23280 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | CA5A | P35218 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alizapride SCHEMBL48937 | 1.00 | DRD2 (0.68) | DRD2DRD3DRD4CA12CA1 | |
| Alizapride SCHEMBL48936 | 0.88 | DRD2 (0.65) | DRD2DRD3DRD4CA12CA1 | |
| Alizapride SCHEMBL30089955 | 0.88 | DRD2 (0.65) | DRD2DRD3DRD4CA12CA1 | |
| Alizapride SCHEMBL3764712 | 0.87 | DRD2 (0.64) | DRD2DRD3DRD4CA12CA1 | |
| Alizapride SCHEMBL18613208 | 0.87 | DRD2 (0.63) | DRD2DRD3DRD4CA12CA1 | |
| SCHEMBL8211543 | 0.84 | DRD2 (0.64) | DRD2DRD3DRD4CA12CA1 | |
| SCHEMBL9835471 | 0.82 | DRD2 (0.69) | DRD2DRD3DRD4CA12CA1 | |
| Alizapride SCHEMBL461456 | 0.81 | DRD2 (0.57) | DRD2DRD3DRD4CA12CA1 | |
| SCHEMBL14962446 | 0.79 | DRD2 (0.56) | DRD2DRD3DRD4CA12CA1 | |
| SCHEMBL11075409 | 0.78 | DRD2 (0.64) | DRD2DRD3DRD4CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017471-A1 | FUNCTIONALITY INDEPENDENT LABELING OF ORGANIC COMPOUNDS | UNIV SHANGHAI TECHNOLOGY (CN) | 2022-01-20 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220017471-A1 | FUNCTIONALITY INDEPENDENT LABELING OF ORGANIC COMPOUNDS | PAICS, PFAS, OTC | DRD2 2476/4885DRD3 1630/4885DRD4 1760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.