Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16494830 | 0.94 | JAK2 (0.47) | JAK2BACE1CCNT1CDK9PTK2 | |
| SCHEMBL16494622 | 0.87 | JAK2 (0.38) | JAK2BACE1CCNT1CDK9NLRP3 | |
| SCHEMBL16494256 | 0.86 | JAK2 (0.47) | JAK2PTK2PTK2BCDC7MAP4K4 | |
| SCHEMBL16494276 | 0.84 | JAK2 (0.47) | JAK2CDK9PTK2PTK2BCDC7 | |
| SCHEMBL16494695 | 0.83 | JAK2 (0.48) | JAK2PTK2PTK2BMAP3K14 | |
| SCHEMBL16495140 | 0.83 | JAK2 (0.47) | JAK2PTK2PTK2BCDC7MAP4K4 | |
| SCHEMBL16495061 | 0.81 | PTK2 (0.46) | BACE1CCNT1CDK9PTK2PTK2B | |
| SCHEMBL16494313 | 0.81 | PTK2 (0.40) | BACE1CCNT1CDK9PTK2PTK2B | |
| SCHEMBL16494867 | 0.81 | PTK2 (0.40) | BACE1CCNT1CDK9PTK2PTK2B | |
| SCHEMBL16494444 | 0.81 | PTK2 (0.46) | BACE1CCNT1CDK9PTK2PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |