Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 3/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16494901 | 0.89 | JAK2 (0.37) | JAK2GSK3BGSK3ABCL6 | |
| SCHEMBL16494695 | 0.87 | JAK2 (0.48) | JAK2PTK2PTK2BMAP3K14AURKA | |
| SCHEMBL16494256 | 0.86 | JAK2 (0.47) | JAK2PTK2PTK2BMAP3K14AURKA | |
| SCHEMBL16494830 | 0.84 | JAK2 (0.47) | JAK2PTK2PTK2BMAP3K14AURKA | |
| SCHEMBL16494276 | 0.83 | JAK2 (0.47) | JAK2PTK2PTK2BAURKBGSK3B | |
| SCHEMBL16494405 | 0.83 | JAK2 (0.48) | JAK2PTK2PTK2BMAP3K14GSK3B | |
| SCHEMBL16495136 | 0.79 | JAK2 (0.42) | JAK2KDR | |
| SCHEMBL16495005 | 0.78 | JAK2 (0.39) | JAK2PTK2AURKAAURKBGSK3B | |
| SCHEMBL16494733 | 0.75 | JAK2 (0.38) | JAK2 | |
| SCHEMBL16495120 | 0.74 | KDR (0.39) | JAK2AURKBGSK3BMAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |