Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | DHPS | P49366 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16494733 | 0.94 | JAK2 (0.38) | JAK2BACE1KCNH2LMNAMAPT | |
| SCHEMBL16494405 | 0.87 | JAK2 (0.48) | JAK2BACE1NLRP3ABL1CCNT1 | |
| SCHEMBL16495005 | 0.85 | JAK2 (0.39) | JAK2KCNH2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL16495120 | 0.84 | KDR (0.39) | JAK2KCNH2MAPK1CREBBP | |
| SCHEMBL16494901 | 0.84 | JAK2 (0.37) | JAK2KCNH2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL16494830 | 0.81 | JAK2 (0.47) | JAK2BACE1ABL1CCNT1CDK9 | |
| SCHEMBL16494619 | 0.78 | JAK2 (0.35) | JAK2CREBBPDHPSSLC2A1 | |
| SCHEMBL16494695 | 0.74 | JAK2 (0.48) | JAK2LMNAMAPTSMN1; SMN2HTT | |
| SCHEMBL16339073 | 0.74 | EGFR (0.40) | JAK2KCNH2LMNAMAPTSMN1; SMN2 | |
| SCHEMBL16494732 | 0.74 | JAK2 (0.35) | JAK2KCNH2LMNAKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |