Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 6/20 | 0.48 |
| ▸ | CLK2 | P49760 | 6/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.48 |
| ▸ | CLK3 | P49761 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | BCL6 | P41182 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16494497 | 0.86 | PTK2 (0.45) | PTK2PTK2BCDK2BCL6MAPK1 | |
| SCHEMBL2598604 | 0.86 | PTK2 (0.45) | PTK2PTK2BCDK2BCL6MAPK1 | |
| SCHEMBL16494444 | 0.83 | PTK2 (0.46) | PTK2PTK2BCDK2BCL6MAPK1 | |
| SCHEMBL16495061 | 0.83 | PTK2 (0.46) | PTK2PTK2BCDK2BCL6MAPK1 | |
| SCHEMBL16494276 | 0.83 | JAK2 (0.47) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL16495191 | 0.78 | PTK2 (0.40) | PTK2PTK2BBCL6MAPK1 | |
| SCHEMBL16494581 | 0.78 | PTK2 (0.40) | PTK2PTK2BBCL6MAPK1 | |
| SCHEMBL12185305 | 0.78 | CLK1 (0.55) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL12185454 | 0.76 | CLK1 (0.53) | CLK1CLK2DYRK1ACLK4DYRK1B | |
| SCHEMBL16494313 | 0.75 | PTK2 (0.40) | CLK1CLK2DYRK1ACLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |