Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 7/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 5/20 | 0.45 |
| ▸ | BCL6 | P41182 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598604 | 1.00 | PTK2 (0.45) | PTK2PTK2BBCL6MAPK1NMT1 | |
| SCHEMBL16494444 | 0.93 | PTK2 (0.46) | PTK2PTK2BBCL6MAPK1PAK4 | |
| SCHEMBL16495061 | 0.93 | PTK2 (0.46) | PTK2PTK2BBCL6MAPK1PAK4 | |
| SCHEMBL16495191 | 0.92 | PTK2 (0.40) | PTK2PTK2BBCL6MAPK1NMT1 | |
| SCHEMBL16494581 | 0.92 | PTK2 (0.40) | PTK2PTK2BBCL6MAPK1NMT1 | |
| SCHEMBL16494524 | 0.86 | CLK1 (0.48) | PTK2PTK2BBCL6MAPK1JAK3 | |
| SCHEMBL16494313 | 0.85 | PTK2 (0.40) | PTK2PTK2BBCL6MAPK1PAK4 | |
| SCHEMBL16494867 | 0.85 | PTK2 (0.40) | PTK2PTK2BBCL6MAPK1PAK4 | |
| SCHEMBL3392875 | 0.84 | NMT1 (0.44) | NMT1PAK4PAK1HDAC1EGFR | |
| SCHEMBL12185447 | 0.82 | PAK1 (0.44) | NMT1PAK4PAK1HDAC1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |