Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | NMT1 | P30419 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16494581 | 1.00 | PTK2 (0.40) | PTK2PTK2BNMT1PAK1PAK4 | |
| SCHEMBL16494867 | 0.93 | PTK2 (0.40) | PTK2PTK2BPAK1PAK4ABL1 | |
| SCHEMBL16494313 | 0.93 | PTK2 (0.40) | PTK2PTK2BPAK1PAK4ABL1 | |
| SCHEMBL16494497 | 0.92 | PTK2 (0.45) | PTK2PTK2BNMT1PAK1PAK4 | |
| SCHEMBL2598604 | 0.92 | PTK2 (0.45) | PTK2PTK2BNMT1PAK1PAK4 | |
| SCHEMBL16494444 | 0.85 | PTK2 (0.46) | PTK2PTK2BPAK1PAK4ABL1 | |
| SCHEMBL16495061 | 0.85 | PTK2 (0.46) | PTK2PTK2BPAK1PAK4ABL1 | |
| SCHEMBL3392875 | 0.84 | NMT1 (0.44) | NMT1PAK1PAK4HDAC1EGFR | |
| SCHEMBL12185464 | 0.82 | PAK1 (0.44) | NMT1PAK1PAK4HDAC1EGFR | |
| SCHEMBL12185447 | 0.82 | PAK1 (0.44) | NMT1PAK1PAK4HDAC1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |