Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.33 |
| ▸ | HTT | P42858 | 6/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.32 |
| ▸ | DHPS | P49366 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | BCL6 | P41182 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495140 | 0.89 | JAK2 (0.47) | JAK2BCL6GSK3AGSK3B | |
| SCHEMBL16495005 | 0.87 | JAK2 (0.39) | JAK2KCNH2LMNAMAPTHTT | |
| SCHEMBL16494733 | 0.85 | JAK2 (0.38) | JAK2KCNH2LMNAMAPTHTT | |
| SCHEMBL16495120 | 0.85 | KDR (0.39) | JAK2KCNH2MAPK1GSK3AGSK3B | |
| SCHEMBL16494622 | 0.84 | JAK2 (0.38) | JAK2KCNH2LMNAMAPTHTT | |
| SCHEMBL16494695 | 0.76 | JAK2 (0.48) | JAK2LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL16494256 | 0.75 | JAK2 (0.47) | JAK2BCL6GSK3B | |
| SCHEMBL16494830 | 0.72 | JAK2 (0.47) | JAK2GSK3B | |
| SCHEMBL16494276 | 0.72 | JAK2 (0.47) | JAK2MAPK1IGF1RGSK3AGSK3B | |
| SCHEMBL16494405 | 0.71 | JAK2 (0.48) | JAK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |