Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.56 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16496182 | 0.95 | HPGDS (0.54) | NPC1ATMSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16495562 | 0.92 | HPGDS (0.53) | NPC1ATMSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16495475 | 0.88 | SMN1; SMN2 (0.56) | NPC1ATMSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL16495574 | 0.86 | TSHR (0.59) | NPC1SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL16495441 | 0.86 | TSHR (0.66) | SMN1; SMN2LMNAALDH1A1TSHRRCE1 | |
| SCHEMBL16495914 | 0.82 | HPGDS (0.60) | L3MBTL1HPGDSCYP2C9CYP2C19 | |
| SCHEMBL16496304 | 0.81 | TRPV1 (0.56) | NPC1SMN1; SMN2EGLN1HPGDSTYRO3 | |
| SCHEMBL16495558 | 0.81 | HPGDS (0.53) | NPC1SMN1; SMN2LMNAALDH1A1TSHR | |
| SCHEMBL16496160 | 0.81 | ALDH1A1 (0.60) | SMN1; SMN2LMNAALDH1A1TSHREGLN1 | |
| SCHEMBL16495989 | 0.80 | GABRA5 (0.60) | SMN1; SMN2LMNAALDH1A1TSHRRCE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | NPC1 236/4885ATM 4137/4885SMN1; SMN2 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.