Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | STAMBP | O95630 | 1/20 | 0.53 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16496362 | 0.90 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2TAAR1PSMD14 | |
| SCHEMBL19654542 | 0.88 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2TAAR1PSMD14 | |
| SCHEMBL16495606 | 0.88 | PSMD14 (0.56) | NPC1RAB9ASMN1; SMN2TAAR1PSMD14 | |
| SCHEMBL10442013 | 0.84 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL16496007 | 0.82 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TAAR1PSMD14 | |
| SCHEMBL16495895 | 0.81 | NAMPT (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL16496303 | 0.79 | TRPV1 (0.56) | NPC1RAB9ASMN1; SMN2TAAR1PSMD14 | |
| SCHEMBL16495589 | 0.79 | HPGDS (0.56) | NPC1RAB9ARXFP1PTPN1PTPN6 | |
| SCHEMBL16495719 | 0.77 | RXFP1 (0.53) | NPC1RXFP1PTPN1PTPN6PTPN11 | |
| SCHEMBL16496188 | 0.76 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2LMNARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | NPC1 236/4885RAB9A 2122/4885SMN1; SMN2 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.