Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ATR | Q13535 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495683 | 0.89 | ROCK2 (0.61) | ALDH1A1SMN1; SMN2TSHRKMT2AMEN1 | |
| SCHEMBL16495372 | 0.89 | TRPV1 (0.64) | ALDH1A1SMN1; SMN2TSHRRAB9AKMT2A | |
| SCHEMBL16495460 | 0.85 | NAMPT (0.61) | ALDH1A1SMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL5934344 | 0.84 | TRPV1 (0.71) | ALDH1A1SMN1; SMN2TSHRRAB9AKMT2A | |
| SCHEMBL5934638 | 0.84 | TRPV1 (0.58) | ALDH1A1SMN1; SMN2TSHRRAB9AKMT2A | |
| SCHEMBL5934783 | 0.83 | CNR1 (0.58) | ALDH1A1SMN1; SMN2RAB9AKMT2AMEN1 | |
| SCHEMBL16496431 | 0.83 | TP53 (0.65) | ALDH1A1SMN1; SMN2TSHRRAB9AKMT2A | |
| SCHEMBL5934845 | 0.83 | KCNK3 (0.60) | ALDH1A1SMN1; SMN2TSHRRAB9AKMT2A | |
| SCHEMBL16496034 | 0.83 | CYP11B1 (0.61) | RAB9ACSF1RLMNANPC1ATR | |
| SCHEMBL5934224 | 0.83 | TP53 (0.55) | ALDH1A1SMN1; SMN2TSHRRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | ALDH1A1 172/4885SMN1; SMN2 1659/4885TSHR 3631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.