Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.64 |
| ▸ | PRKDC | P78527 | 1/20 | 0.63 |
| ▸ | ATR | Q13535 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.59 |
| ▸ | PLAU | P00749 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.56 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5934344 | 0.93 | TRPV1 (0.71) | TRPV1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL16495683 | 0.91 | ROCK2 (0.61) | TRPV1PRKDCATRNPC1SMN1; SMN2 | |
| SCHEMBL16496431 | 0.90 | TP53 (0.65) | TRPV1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5934783 | 0.90 | CNR1 (0.58) | TRPV1PRKDCATRNPC1RAB9A | |
| SCHEMBL16495668 | 0.89 | ALDH1A1 (0.69) | ATRNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5934208 | 0.88 | TP53 (0.68) | TRPV1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL6174432 | 0.88 | MAPT (0.55) | PRKDCATRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5934638 | 0.88 | TRPV1 (0.58) | TRPV1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5934845 | 0.87 | KCNK3 (0.60) | TRPV1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5934270 | 0.87 | TRPV1 (0.57) | TRPV1NPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | TRPV1 116/4885PRKDC 4855/4885ATR 4692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.