Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.61 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | PLAU | P00749 | 2/20 | 0.54 |
| ▸ | PLG | P00747 | 1/20 | 0.54 |
| ▸ | PLAT | P00750 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PRKDC | P78527 | 1/20 | 0.53 |
| ▸ | ATR | Q13535 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495372 | 0.91 | TRPV1 (0.64) | ROCK2KMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL16495668 | 0.89 | ALDH1A1 (0.69) | ROCK2PRKG1KMT2AMEN1LMNA | |
| SCHEMBL5934783 | 0.88 | CNR1 (0.58) | KMT2AMEN1SMN1; SMN2ALDH1A1PLAU | |
| SCHEMBL16496431 | 0.88 | TP53 (0.65) | ROCK2PRKG1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6174432 | 0.86 | MAPT (0.55) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5934208 | 0.86 | TP53 (0.68) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL16495626 | 0.85 | NT5E (0.64) | ROCK2KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL5934217 | 0.84 | BRAF (0.55) | KMT2AMEN1LMNASMN1; SMN2TSHR | |
| SCHEMBL5934458 | 0.84 | ABCG2 (0.53) | KMT2AMEN1LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5934344 | 0.84 | TRPV1 (0.71) | KMT2AMEN1SMN1; SMN2POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | ROCK2 4683/4885PRKG1 3173/4885KMT2A 3206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.