Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.60 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.60 |
| ▸ | PRKACA | P17612 | 2/20 | 0.60 |
| ▸ | AKT1 | P31749 | 2/20 | 0.60 |
| ▸ | PRKACG | P22612 | 1/20 | 0.60 |
| ▸ | PRKACB | P22694 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | HPGDS | O60760 | 3/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.54 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.54 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.51 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16496342 | 0.88 | BAZ2B (0.65) | ROCK2PRKG1PRKACAAKT1PRKACG | |
| SCHEMBL16496311 | 0.87 | ROCK2 (0.79) | ROCK2PRKG1PRKACAAKT1PRKACG | |
| SCHEMBL16495423 | 0.87 | NPC1 (0.69) | ROCK2PRKG1PRKACAAKT1PRKACG | |
| SCHEMBL16495932 | 0.87 | HPGDS (0.64) | ROCK2PRKG1PRKACAAKT1PRKACG | |
| SCHEMBL16495506 | 0.84 | HPGDS (0.55) | ROCK2PRKG1PRKACAAKT1HPGDS | |
| SCHEMBL16495904 | 0.84 | ROCK2 (0.74) | ROCK2PRKG1PRKACAAKT1PRKACG | |
| SCHEMBL16495476 | 0.84 | HPGDS (0.54) | ROCK2PRKG1PRKACAAKT1PRKACG | |
| SCHEMBL16495384 | 0.83 | HPGDS (0.58) | ROCK2PRKG1PRKACAAKT1PRKACG | |
| SCHEMBL16496073 | 0.82 | HPGDS (0.52) | ROCK2PRKG1PRKACAAKT1PRKACG | |
| SCHEMBL16495567 | 0.82 | HPGDS (0.60) | ROCK2PRKG1PRKACAAKT1PRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | ROCK2 4683/4885PRKG1 3173/4885PRKACA 4265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.