Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Senazodan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
| ▸ | PDE3B | Q13370 | 13/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.56 |
| ▸ | PDE4A | P27815 | 4/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPY1R | P25929 | 1/20 | 0.47 |
| ▸ | NPY2R | P49146 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Senazodan SCHEMBL1652002 | 0.98 | KCNH2 (1.00) | KCNH2PDE3BPDE3APDE4APDE4B | |
| Senazodan SCHEMBL4519202 | 0.97 | KCNH2 (0.97) | KCNH2PDE3BPDE3APDE4APDE4B | |
| Senazodan SCHEMBL4526209 | 0.96 | KCNH2 (0.94) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7263634 | 0.84 | KCNH2 (0.73) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10548193 | 0.82 | KCNH2 (0.71) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7264027 | 0.81 | KCNH2 (0.70) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10353452 | 0.80 | SMN1; SMN2 (0.81) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10474131 | 0.80 | KCNH2 (0.67) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL2478615 | 0.78 | KCNH2 (0.66) | KCNH2PDE3BPDE3APDE4APDE4B | |
| SCHEMBL22910067 | 0.78 | KCNH2 (0.66) | KCNH2PDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |