Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148593 | 0.92 | CYP1A2 (0.43) | KDM4EALDH1A1HPGDMAPK14GAA | |
| SCHEMBL16511450 | 0.89 | MEN1 (0.36) | KDM4EALDH1A1HPGDMAPK14GAA | |
| SCHEMBL16497634 | 0.87 | ALOX5 (0.42) | KDM4EMAPK14ALOX5MEN1KMT2A | |
| SCHEMBL14690033 | 0.86 | DRD2 (0.38) | MAPK14GAAMEN1KMT2AF11 | |
| SCHEMBL16510872 | 0.84 | MEN1 (0.38) | MAPK14MEN1KMT2AF11AKT1 | |
| SCHEMBL16497623 | 0.83 | MEN1 (0.40) | KDM4EALDH1A1HPGDMAPK14HSD17B10 | |
| SCHEMBL16511414 | 0.83 | NPSR1 (0.40) | MAPK14MEN1KMT2AF11LMNA | |
| SCHEMBL16497631 | 0.83 | MEN1 (0.45) | MAPK14MEN1KMT2AF11AKT1 | |
| SCHEMBL16497629 | 0.82 | BRAF (0.44) | MAPK14MEN1KMT2AF11AKT1 | |
| SCHEMBL16497611 | 0.82 | RAF1 (0.48) | KDM4EALDH1A1HPGDMAPK14GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011038261-A1 | HETEROCYCLIC KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2011-03-31 | — | — | WO | disclosed |
| WO-2011038261-A1 | HETEROCYCLIC KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2011-03-31 | — | — | WO | disclosed |