Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 10/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16497609 | 0.92 | KDM4E (0.40) | CYP1A2CYP3A4CYP2C19CYP2D6LMNA | |
| SCHEMBL14690033 | 0.87 | DRD2 (0.38) | MAPK14MAPTMEN1KMT2AGAA | |
| SCHEMBL2148279 | 0.85 | PIN1 (0.41) | MAPK1MAPK14MAPTMEN1KMT2A | |
| SCHEMBL16497634 | 0.83 | ALOX5 (0.42) | CYP3A4CYP2C19CYP2D6LMNACYP2C9 | |
| SCHEMBL2145931 | 0.82 | TEK (0.39) | CYP3A4MAPK14NPC1MAPTMEN1 | |
| SCHEMBL14690185 | 0.82 | MAPK14 (0.41) | MAPK14NPC1MAPTMEN1KMT2A | |
| SCHEMBL16511450 | 0.82 | MEN1 (0.36) | ALDH1A1MAPK14MAPTHSD17B10KDM4E | |
| SCHEMBL14701090 | 0.81 | MAPK14 (0.43) | MAPK14MEN1KMT2AGAA | |
| SCHEMBL16510872 | 0.80 | MEN1 (0.38) | CYP3A4CYP2C19CYP2D6LMNACYP2C9 | |
| SCHEMBL14701092 | 0.80 | PDE4D (0.42) | CYP1A2CYP3A4CYP2C19LMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040983-A1 | RAF KINASE INHIBITORS | RUGA CORPORATION | 2013-02-14 | — | — | US | disclosed |
| WO-2011085269-A1 | RAF KINASE INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040983-A1 | RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | CYP1A2 4229/4885CYP3A4 4360/4885CYP2C19 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.