Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | STAT1 | P42224 | 1/20 | 0.59 |
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | METAP2 | P50579 | 3/20 | 0.49 |
| ▸ | METAP1 | P53582 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | WNT1 | P04628 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16497806 | 0.85 | KDM4E (0.51) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL16499476 | 0.81 | ALDH1A1 (0.65) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL13866553 | 0.80 | NPC1 (0.74) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL10351277 | 0.79 | NPC1 (0.68) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL16498271 | 0.79 | NPC1 (0.63) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL14837509 | 0.78 | MAPT (0.60) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL14837956 | 0.77 | QPCT (0.71) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL10175464 | 0.77 | CYP11B1 (0.79) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL14297289 | 0.76 | CYP2A6 (0.62) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6509350 | 0.76 | MAPT (0.69) | NPC1RAB9AKDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151618-A2 | COMPOUNDS FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE-ASSOCIATED DISEASE | SUMMIT CORPORATION PLC (GB) | 2011-12-08 | — | — | WO | claimed |