Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | WEE1 | P30291 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906715 | 0.89 | MAPT (0.41) | MAPTMEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7920135 | 0.85 | MAPT (0.46) | MAPTMEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL16502484 | 0.84 | RAB9A (0.44) | MAPTMEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7906753 | 0.79 | MAPT (0.36) | MAPTMEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7916826 | 0.78 | HTR5A (0.51) | — | |
| SCHEMBL7915719 | 0.78 | RAB9A (0.40) | MAPTMEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7916811 | 0.77 | CCNT1 (0.40) | MAPTMEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7908906 | 0.76 | PLAU (0.34) | MAPTMEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7916763 | 0.76 | RAB9A (0.35) | MAPTMEN1ALDH1A1RAB9AKMT2A | |
| SCHEMBL7916827 | 0.76 | PLAU (0.33) | MAPTMEN1KMT2APLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394987-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-14 | — | — | EP | disclosed |