Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 5/20 | 0.34 |
| ▸ | THRA | P10827 | 4/20 | 0.34 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 2/20 | 0.33 |
| ▸ | TTR | P02766 | 2/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7918238 | 0.86 | TTR (0.48) | HSP90AA1THRBTHRATTRKDM4E | |
| SCHEMBL7918472 | 0.83 | HSD17B14 (0.36) | HSP90AA1THRBCTDSP1TTRHSD17B1 | |
| SCHEMBL7918345 | 0.82 | CYP1A2 (0.40) | HSP90AA1KDM4EALDH1A1GLACYP1A2 | |
| SCHEMBL7906715 | 0.82 | MAPT (0.41) | HSP90AA1WEE1CHEK1KDM4EALDH1A1 | |
| SCHEMBL7915836 | 0.77 | GRM2 (0.35) | THRBTHRAF2PLGPLAU | |
| SCHEMBL7917270 | 0.77 | HTR2B (0.51) | — | |
| SCHEMBL7637791 | 0.77 | CYP1A2 (0.52) | HSP90AA1THRBTHRAKDM4EALDH1A1 | |
| SCHEMBL7908665 | 0.77 | PLA2G2D (0.49) | THRBTHRATTRKDM4ETSHR | |
| SCHEMBL16503471 | 0.76 | DOT1L (0.39) | HSP90AA1KDM4EALDH1A1TSHRF2 | |
| SCHEMBL7920129 | 0.74 | TNF (0.45) | HSD17B1HSD17B2KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2394987-A1 | ACYLGUANIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2011-12-14 | — | — | EP | disclosed |